PHIME Public health impact of long-term, low-level mixed element exposure in susceptible population strata

Country: EU Projects
Start Date:   25/2/2006         Duration: 60 months         Project Type: RTD
Contract Number: 16253
Organisation Type:  EC Project
Contaminated land-->Contaminants-->Heavy metals
Contaminated land-->Risk assessment-->Receptor: Human health
Diffuse pollution-->Contaminants-->Contaminants overview
Diffuse pollution-->Processes
Project objectives:
Abstract The project will contain four pillars, each with several work packages (with several sub-projects). In addition, there will be cross-cutting work 
packages. I. What are the problems? i) We will epidemiologically assess the impact of toxic metals (particularly cadmium, mercury, lead and manganese) exposure
through foods on diseases of public health concern (nervous system, cardiovascular, osteoporosis/fractures, kidneys, diabetes). Some studies will utilize
unique biobank material. ii) Particular interest will be paid to interaction between toxic elements in mixed exposures (several metals and other pollutants),
and on ???new??? elements (platinum, palladium, rhodium and manganese). iii) We will characterize benefits of exposures to essential elements (selenium,
zinc)/other dietary components (fatty acids, fibre), and describe some aspects of risk/benefit relationships. iv) We will address pathomechanisms. v)
We will focus on susceptible groups (fetuses/infants/children, fertile women and elderly, nutrition and gene-environment interactions), as regards metabolism
and toxic effects. II. Where are the problems? vi) We will develop and validate new methods for biomonitoring of exposures. vii) We will define geographical
patterns/sources of exposure in EU Member States, especially in children and women. viii) We will assess time trends of exposure, retrospective and prospectively.
III. Possible solutions to the problems ix) We will develop probabilistic models, describing the exposures and exposure-response patterns.
Project Summary:
This project will enable scientifically-based decisions by national, EU and international bodies on preventive actions. x) We will explore mechanisms of 
uptake and distribution of toxic and essential elements in plants, which will make it possible to breed species with low concentrations of toxic elements and
high of essential. This gives a possibility to change the intakes through plant foods and the transportation into animal foods
Achieved Objectives:

Product Descriptions:

Additional Information:
Project Resources:

PHIME: Public Health Impact of long-term, low-level Mixed Element Exposure in susceptible population strata
Funding Programme(s): 
EC Framework Programme 6
Link to Organisations:
Submitted by: EUGRIS Team Professor Paul Bardos  Who does what?  28/11/2017 14:21:00