| Title: |
Exposure to armament wastes and leukemia: a case-control study within a cluster of AML and CML in Germany
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| Resource Type: |
document --> technical publication --> journal article
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| Country: |
Germany
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| Year: |
2001 |
| Availability: |
Leukemia Research 25 (10) 839-45.
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| Author 1/Producer: |
Kilian PH
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| Other Authors/Producers: |
Skrzypek S, Becker N, Havemann K.
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| Author / Producer Type: |
University research group / research institute
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| Publisher: |
Elsevier
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EUGRIS Keyword(s): |
Contaminated land-->Risk assessment-->Exposure pathways
Contaminated land-->Risk assessment-->Receptor: Human health
Contaminated land-->Risk assessment-->Toxicological information
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| Short description: |
An unusually high incidence of acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) concentrated in a specific locality of a region in Germany motivated a descriptive incidence study in that region which showed a near 10-fold increased risk of CML among males but not among females. Since a serious environmental contamination of areas in this locality with armament wastes containing toluene-derivatives has been known for a long time, the hypothesis arose that TNT production and the related severe contamination of soil and water might be responsible for the observed higher risk. This case control study found that there is an indication of a relationship of an increased odds ratio with the exposure for a small group of persons who lived at a particular site in one of the two communities involved during the peak phase of TNT production during the 1940s. However, this finding is spurious and cannot explain the large majority of cases which occurred in that area in the 1980s. At the moment, no other explanation can be given for the increased risk of leukemias in that area.
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Submitted By:
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Professor Paul Bardos WhoDoesWhat?
Last update: 28/09/2007
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