Title: Assessment of dioxine-like toxicities of water-exposed SPMDs by in vitro reporter gene bioassay 
Resource Type: document --> technical publication --> proceedings / conference paper(s) 
Country: EU Projects 
Year of publication: 2003 
Availability: Janošek, J. & Bláha, L. (2003) Assessment of dioxine-like toxicities of water-exposed SPMDs by in vitro reporter gene bioassay. Persistent Toxic Substances Contamination of the European Region as a reflection of results of the GEF/UNEP Regional Based Assessment of Persistent Toxic Substances (RBA PTS) in Europe, the implementation of the Stockholm Convention and 'Community Strategy for Dioxins, Furans and PCBs 
Author 1/Producer: Janošek, J. 
Other Authors/Producers: Bláha, L. 
Author / Producer Type: EC Project 
Report / download web link (=direct link): http://www.recetox.muni.cz/coe/sources/workshop_1_rba_pts/VI ...  
EUGRIS Keyword(s): Diffuse pollution-->Contaminants-->Persistent Organic Pollutants
Short description: Semi-permeable membrane devices (SPMD) are passive sampling devices suitable for concentration of trace contaminants from the environment. In this presentation we summarize results of pilot experiments with applications of the in vitro reporter gene bioassay (H4IIE.luc cells) for assessment of AhR-mediated ('dioxin-like') toxicities of SPMDs exposed in waters in localities in the Czech Republic. Observed AhR-mediated effects were in good correlation with the content of dioxin-like compounds (such as PCDD/Fs, PCBs and PAHs) and the results confirmed suitability of the reporter gene bioassay as a rapid and specific in vitro biomarker tool. 
Link to Project(s): RECETOX Centre of Excellence in Environmental Chemistry and Ecotoxicology
Submitted By: Dr Stefan Gödeke WhoDoesWhat?      Last update: 14/02/2006

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