Title: |
Assessment of dioxine-like toxicities of water-exposed SPMDs by in vitro reporter gene bioassay
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Resource Type: |
document --> technical publication --> proceedings / conference paper(s)
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Country: |
EU Projects
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Year of publication: |
2003 |
Availability: |
Janošek, J. & Bláha, L. (2003) Assessment of dioxine-like toxicities of water-exposed SPMDs by in vitro reporter gene bioassay. Persistent Toxic Substances Contamination of the European Region as a reflection of results of the GEF/UNEP Regional Based Assessment of Persistent Toxic Substances (RBA PTS) in Europe, the implementation of the Stockholm Convention and 'Community Strategy for Dioxins, Furans and PCBs
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Author 1/Producer: |
Janošek, J.
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Other Authors/Producers: |
Bláha, L.
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Author / Producer Type: |
EC Project
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EUGRIS Keyword(s): |
Diffuse pollution-->Contaminants-->Persistent Organic Pollutants
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Short description: |
Semi-permeable membrane devices (SPMD) are passive sampling devices suitable for concentration of trace contaminants from the environment. In this presentation we summarize results of pilot experiments with applications of the in vitro reporter gene bioassay (H4IIE.luc cells) for assessment of AhR-mediated ('dioxin-like') toxicities of SPMDs exposed in waters in localities in the Czech Republic. Observed AhR-mediated effects were in good correlation with the content of dioxin-like compounds (such as PCDD/Fs, PCBs and PAHs) and the results confirmed suitability of the reporter gene bioassay as a rapid and specific in vitro biomarker tool.
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Submitted By:
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Dr Stefan Gödeke WhoDoesWhat?
Last update: 14/02/2006
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