Title: Bioavailability of dioxins and dioxin-like compounds in soil 
Resource Type: document --> technical publication --> report 
Country: USA 
Year: 2010 
Availability: December 20, 2010 
Author 1/Producer: US Environmental protection Agency (US EPA) 
Other Authors/Producers: SRC, Inc 
Author / Producer Type: Agency, regulator or other governmental or inter-governmental body 
Report / download web link (=direct link): http://epa.gov/superfund/health/contaminants/dioxin/pdfs/Fin ...  
Format (e.g. PDF): PDF 
EUGRIS Keyword(s): Contaminated land-->Contaminants-->Others
Contaminated land-->Risk assessment-->Exposure pathways
Diffuse pollution-->Contaminants-->Persistent Organic Pollutants
 
Short description: The Risk Assessment Guidance for Superfund (RAGS) Part A discusses making adjustments to Superfund site-specific risk assessments when the medium of exposure in an exposure assessment differs from the medium of exposure assumed by the toxicity value (cancer slope factor, reference dose value, etc.) based upon site-specific bioavailability data. An important consideration in assessing risks from exposures to dioxin in soil is whether an adjustment is needed in the application of the oral cancer slope factor (CSF) and/or oral chronic reference dose (RfD) for 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD). This adjustment would account for differences in the bioavailability of TCDD (and toxicologically related polychlorinated dibenzo-p-dioxins [PCDD] and polychlorinated dibenzofuran congeners [PCDF]) in soil and in the test medium used in the critical study(s) on which the CSF and/or RfD were based (e.g., dietary exposure vs. exposure to soil). An adjustment would be considered appropriate if evidence were sufficient to indicate that the relative bioavailability (RBA) of the PCDD/F mixture in soil was less than 100%. This report presents a summary of the published literature and analysis of the available data regarding RBA of PCDD/F in soil 
Link to News Items(s):   US EPA TechDirect, March 1, 2011
Submitted By: Professor Paul Bardos WhoDoesWhat?      Last update: 01/03/2011

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