Title: PCBs May Impede IVF Success: Failed Embryo Implantation Linked to Exposure 
Resource Type: document --> technical publication --> journal article 
Country: USA 
Year: 2011 
Availability: Environ Health Perspect 119:a307-a307. doi:10.1289/ehp.119-a307a On line 1/7/11 
Author 1/Producer: Barrett JR 2011 
Author / Producer Type: Media and publishers sector 
Article Weblink (=direct link): http://ehp03.niehs.nih.gov/article/fetchArticle.action?artic ...  
EUGRIS Keyword(s): Contaminated land-->Contaminants-->Others
Contaminated land-->Risk assessment-->Receptor: Human health
Diffuse pollution-->Contaminants-->Persistent Organic Pollutants
Short description: EXTRACT: Women with PCB 118 and group 3 congener concentrations above the lowest quartile also were more likely to have a failed implantation than women with the lowest exposures, although the associations did not increase with each increase in dose. Odds of a live birth were lower for women in the highest versus lowest quartiles of PCB 153 and ÓPCB exposure, while PCB 118 and group 2 and 3 congeners were associated with smaller nonsignificant reductions in live births. The study has several strengths, including its prospective design and PCB measurement at the start of attempted pregnancy. However, unknown confounding factors, additional reproduction-related end points for PCB toxicity, relevance of these results to women not undergoing IVF, and a lack of data on male factors are gaps that need to be filled in future studies. 
Submitted By: Professor Paul Bardos WhoDoesWhat?      Last update: 08/07/2011

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