Enrieco Environmental Health Risks in European Birth Cohorts

There are many pregnancy and birth cohorts in Europe, with sample sizes ranging from a few hundreds to tens of thousands.  A number of them aim to examine environment 
and health relationships, but the sample sizes are often too small to lead to conclusive results on their own, or have led to inconsistent and sometimes opposite 
results.  Furthermore the environmental exposure assessment often is the weakest part in the studies as a result of lack of funding and expertise, and could 
be improved.   
  
Nevertheless, these cohorts often contain high quality data in many areas such as outcomes and possible confounders and have a team of highly experienced 
researchers working on them with great expertise and commitment.  A number of the cohorts participate in one or more EC funded studies such as GA2LEN (biological 
exposures and asthma and allergy), ESCAPE (air pollution and allergy asthma, infections, cognitive function and pregnancy outcomes), INUENDO (POPs and 
reproductive health), HIWATE (water contaminants and still birth, congenital anomalies, birth weight, preterm delivery), HITEA (indoor exposures and 
asthma and allergies) and NEWGENERIS (food contaminants and genotoxic risks) and provide a great resource to explore environmental exposure response relationships, 
but lack at times coordination, expertise and funding to make the best and most efficient use of the available resources.  
  
In addition exposure-response data may be available but not easily accessible, are based on small numbers and should be combined or at least compared with 
information from other studies.  Furthermore, while a number of the cohorts have been following up children for many years, others have just started with follow 
up of pregnant women/foetus and provide an excellent resource for future follow up into childhood to examine the existence of vulnerable periods during pregnancy 
and childhood for a range of environmental pollutants.  The exchange of information and experience between the older and newer cohorts is essential to formulate 
new hypotheses and use the best methods, tools and study designs to test these hypotheses.  
  
The aims and objectives of the coordination project is to bring together cohorts with environment and health information, share resources, expertise and 
experience in this area, extract environmental exposure response relationships, where available, and evaluate the information and build common databases 
to explore environmental exposure response relationships, where possible and needed. Protocols will be developed for the evaluation and could be used for 
other projects. Furthermore, the project will evaluate potential new uses of the cohorts such as new exposures and health outcomes, and make recommendations.