Project objectives:
Nanofate will deliver a systematic study of the environmental fate and toxicity of selected ENPs, to support delivery of novel ENP risk quantification methods.
Nine Science & Technology objectives are addressed:
1 Design, tagging and manufacture of ENPs
2 Analysis of ENP interactions with abiotic and biotic entities
3 Generating predictive models for ENP exposure in waters and sludge-amended soils
4 Studying the fate and behaviour of ENPs through wastewater treatment
5 Determining acute and chronic ecotoxicity
6 Assessing effects of physico-chemical properties on ENP bioavailability
7 Defining mechanisms of uptake, internal trafficking, and toxicity
8 Developing spatial risk assessment model(s)
9 Improving understanding of ENP risks
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Project
Summary:
Concept: NanoFATE has been conceived to fill knowledge and methodological gaps currently impeding sound assessment
of environmental risks posed by engineered nanoparticles (ENPs). Our vision is to assess environmental fate and risk of
ENPs from high-volume products for which recycling is not an option; namely; fuel additive, personal care and antibacterial
products. Two market ENPs from each product (CeO2, ZnO, Ag of varying size, surface and core chemistries) will be
followed through their post-production life cycles i.e. from environmental entry as “spent product”, through waste treatment
to their final fates and potential toxic effects. This will test the applicability of current fate and risk assessment methods and
identify improvements required for a scientific assessment of ENPs at an early stage. Objectives: Such systematic study
of the environmental fate and toxicity of selected ENPs will entail addressing 9 S&T objectives: 1: Design, tagging and
manufacture of ENPs 2: Analysis of ENP interactions with abiotic and biotic entities 3: Generating predictive models for
ENP exposure in waters and sludge-amended soils 4: Studying the fate and behaviour of ENPs through wastewater
treatment 5: Determining acute and chronic ecotoxicity 6: Assessing effects of physico-chemical properties on ENP
bioavailability 7: Defining mechanisms of uptake, internal trafficking, and toxicity 8: Developing spatial RA model(s) 9:
Improving understanding of ENP risks Methodology: The work plan is designed to progress beyond the state-of-the-art
through focused workpackages. While some objectives are delivered in single WPs, good cross WP integration will secure
the key objectives of delivering new methods for quantifying ENP risks. Impact: NanoFATE will provide robust tools,
techniques and knowledge needed by stakeholders to understand and communicate risks associated with different ENPs,
including their environmental interactions and toxicity.
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Professor Paul Bardos