| Title: |
Effects of 17ß-estradiol exposure in the mussel Mytilus galloprovincialis.
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| Resource Type: |
document --> technical publication --> journal article
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| Country: |
EU Projects
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| Year: |
2004 |
| Availability: |
Janer G, Lavado R, Thibaut R, Porte C (2004): Effects of 17ß-estradiol exposure in the mussel Mytilus galloprovincialis. Mar. Environ. Res. 58, 443-446
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| Author 1/Producer: |
Janer G
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| Other Authors/Producers: |
Lavado R, Thibaut R, Porte C
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| Author / Producer Type: |
EC Project
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| Format (e.g. PDF): |
PDF
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EUGRIS Keyword(s): |
Contaminated land-->Contaminants-->Contaminants overview
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| Short description: |
Mussels Mytilus galloprovincialis were exposed to different concentrations of estradiol (20,
200, and 2000 ng/l) in a semi-static regime (1-day dosing intervals) for up to 7 days in an
attempt to see how mussels dealt with exogenous estrogenic compounds. Sex hormone levels
were determined in whole tissue. Free-estradiol was only significantly elevated at the highest
exposure dose (up to 10-fold). Most of the estradiol was in the tissues as fatty acid esters
(>78%), which sharply increased in a dose-dependent manner (from 4 ng/g in controls to 258
ng/g at the high exposure group). In contrast, neither free nor esterified testosterone levels
showed significant differences between control and exposure groups. The results suggest the
existence of mechanisms that allow mussels to maintain their hormonal status, and the important
role that fatty acid esterification may play within those mechanisms. Synthesis and
conjugation rates of estradiol were further investigated by measuring the activity of P450
aromatase, and palmitoyl-CoA:estradiol acyltransferase, in digestive gland microsomal fractions.
Overall, the study contributes to the better knowledge of molluscan endocrinology, and
defines new mechanisms of regulation of free steroid-levels in mussels.
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Submitted By:
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Dr Stefan Gödeke WhoDoesWhat?
Last update: 14/02/2006
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