| Title: |
Principles of health based assessment of chemical substances with respect to the setting of quality criteria for air, soil and water
|
| Resource Type: |
document --> technical publication --> report
|
| Country: |
Denmark
|
| Language(s): |
Danish
English
|
| Year: |
2004 |
| Availability: |
Environmental project, Miljørapport nr. 974
|
| Author 1/Producer: |
Nielsen, Elsa
|
| Other Authors/Producers: |
Østergaard, Grete; Larsen, John Christian; Ladefoged, O.
|
| Author / Producer Type: |
Agency, regulator or other governmental or inter-governmental body
|
| Publisher: |
The Danish Environmental Protection Agency, Miljøstyrelsen
|
| Publisher City: |
Strandgade 29, DK-1405 Copenhagen K, Denmark
|
| ISBN: |
87-7614-488-7
|
| Format (e.g. PDF): |
PDF
|
| Size: (e.g. 20mb) |
700
|
|
EUGRIS Keyword(s): |
Contaminated land-->policy and regulatory
|
| Short description: |
The objective is to review the newest developments in risk assessment of chemical substances and incorporate vital aspects in a new guideline on the principles for the setting of health based quality criteria in soil, drinking water and ambient air, but with due regard for the principles previously in force.
|
| Long description: |
The scientific basis for the assessment of health based quality criteria for chemical substances in soil, drinking water and ambient air consists of a hazard identification, a dose – response assessment (hazard characterisation), and an exposure assessment.
The most critical effect is identified and can either be a threshold effect or an effect which gives some risk at any level (non-threshold, e.g. genotoxic carcinogens). The threshold effect allows the derivation of the tolerable daily intake (TDI) by dividing the NOAEL (or LOAEL) with uncertainty factors; UFI, UFII and UFIII. UFI accounts for the interspecies variation (max. 10), UFII accounts for the differences in inter-individual susceptibility (max 10) and UFIII accounts for the quality and relevance of the data (max 100).
For non-threshold effects, the One-hit model or alternatively, the T25-approach are recommended and a lifetime risk of 10-6 is applied.
|
|
Submitted By:
|
Dr Jacqueline Falkenberg WhoDoesWhat?
Last update: 31/01/2007
|
|
|
