| Title: |
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
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| Resource Type: |
document --> technical publication --> journal article
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| Country: |
USA
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| Year: |
2008 |
| Availability: |
Proc Nat Acad Sci 104 13056-13061
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| Author 1/Producer: |
Dolinoy, D.C.
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| Other Authors/Producers: |
Huang, d. and Jirtle, R.L.
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| Author / Producer Type: |
University research group / research institute
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EUGRIS Keyword(s): |
Contaminated land-->Risk assessment-->Toxicological information
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| Short description: |
Extract: The hypothesis of fetal origins of adult disease posits that early developmental exposures involve epigenetic modifications, such as DNA methylation, that influence adult disease susceptibility. In utero or neonatal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function. This study shows that maternal exposure to this endocrine-active compound shifted the coat color distribution of viable yellow agouti...
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Submitted By:
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Professor Paul Bardos WhoDoesWhat?
Last update: 06/03/2008
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