| Title: |
Bioavailability of dioxins and dioxin-like compounds in soil
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| Resource Type: |
document --> technical publication --> report
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| Country: |
USA
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| Year: |
2010 |
| Availability: |
December 20, 2010
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| Author 1/Producer: |
US Environmental protection Agency (US EPA)
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| Other Authors/Producers: |
SRC, Inc
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| Author / Producer Type: |
Agency, regulator or other governmental or inter-governmental body
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| Format (e.g. PDF): |
PDF
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EUGRIS Keyword(s): |
Contaminated land-->Contaminants-->Others
Contaminated land-->Risk assessment-->Exposure pathways
Diffuse pollution-->Contaminants-->Persistent Organic Pollutants
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| Short description: |
The Risk Assessment Guidance for Superfund (RAGS) Part A
discusses making adjustments to Superfund site-specific risk
assessments when the medium of exposure in an exposure
assessment differs from the medium of exposure assumed by the
toxicity value (cancer slope factor, reference dose value, etc.)
based upon site-specific bioavailability data. An important
consideration in assessing risks from exposures to dioxin in
soil is whether an adjustment is needed in the application of
the oral cancer slope factor (CSF) and/or oral chronic reference
dose (RfD) for 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD). This
adjustment would account for differences in the bioavailability
of TCDD (and toxicologically related polychlorinated
dibenzo-p-dioxins [PCDD] and polychlorinated dibenzofuran
congeners [PCDF]) in soil and in the test medium used in the
critical study(s) on which the CSF and/or RfD were based (e.g.,
dietary exposure vs. exposure to soil). An adjustment would be
considered appropriate if evidence were sufficient to indicate
that the relative bioavailability (RBA) of the PCDD/F mixture in
soil was less than 100%. This report presents a summary of the
published literature and analysis of the available data
regarding RBA of PCDD/F in soil
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Submitted By:
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Professor Paul Bardos WhoDoesWhat?
Last update: 01/03/2011
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