Title: Dioxin Exposure, from Infancy through Puberty, Produces Endocrine Disruption and Affects Human Semen Quality 
Resource Type: document --> technical publication --> journal article 
Country: Italy 
Year: 2008 
Availability: Env Health Perspectives, Vol 116, pp70-77 
Author 1/Producer: Paolo Mocarelli 
Other Authors/Producers: Pier Mario Gerthoux, Donald G. Patterson Jr., Silvano Milani, Giuseppe Limonta, Maria Bertona, Stefano Signorini, Pierluigi Tramacere, Laura Colombo, Carla Crespi, Paolo Brambilla, Cecilia Sarto, Vittorio Carreri, Eric J. Sampson, Wayman E. Turner, and Larry L. Needham 
Author / Producer Type: University research group / research institute 
Article Weblink (=direct link): http://www.ehponline.org/docs/2007/10399/abstract.html  
EUGRIS Keyword(s): Contaminated land-->Contaminants-->Others
Contaminated land-->Risk assessment-->Toxicological information
Diffuse pollution-->Contaminants-->Persistent Organic Pollutants
Short description: Exposure to TCDD in infancy reduces sperm concentration and motility, and an opposite effect is seen with exposure during puberty. Exposure in either period leads to permanent reduction of estradiol and increased FSH. These effects are permanent and occur at TCDD concentrations < 68 ppt, which is within one order of magnitude of those in the industrialized world in the 1970s and 1980s and may be responsible at least in part for the reported decrease in sperm quality, especially in younger men. 
Submitted By: Professor Paul Bardos WhoDoesWhat?      Last update: 06/02/2008

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